L2V (p.Leu2Val) variant of CD276 (CD276 antigen)
L2V (p.Leu2Val) in CD276 (CD276 antigen) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
L2V (p.Leu2Val) variant details
- p.Leu2Val
- NCI-TCGA Cosmic COSV1005
- cosmic curated COSV10057
- NCI-TCGA Cosmic COSV5920
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.312
- REVEL 0.05
- CADD 16.60
- PolyPhen-2 0.01
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available