IL1RAPL2 (X-linked interleukin-1 receptor accessory protein-like 2) variants and mutations

IL1RAPL2 (also known as X-linked interleukin-1 receptor accessory protein-like 2) is a human protein-coding gene encoding a x-linked interleukin-1 receptor accessory protein-like 2 protein. A single-pass cell-surface protein in the interleukin-1 receptor accessory-protein family. Its precise molecular function remains incompletely characterized, but its membrane localization and receptor-like architecture suggest a role in cell-surface signaling. This analysis covers 785 IL1RAPL2 variants and mutations. Of these, 61% have computational variant effect predictions. Disease context includes osteoarthritis, hip, central nervous system cancer, and non-small cell lung carcinoma. Example IL1RAPL2 variants include M1?, P3A, and P3L.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable IL1RAPL2 variants

Examples include M1?, P3A, P3L, P3T, P4S, F5L, F5C, L6F. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.