CD7 (T-cell antigen CD7) variants and mutations

CD7 (also known as T-cell antigen CD7) is a human protein-coding gene encoding a t-cell antigen protein. It contributes to signaling and interactions of T cells and natural-killer cells and is expressed early during lymphoid development. Its frequent expression on T-cell malignancies makes it useful diagnostically and an emerging target for cellular and antibody-based therapies. This analysis covers 637 CD7 variants and mutations. Of these, 95% have computational variant effect predictions. Disease context includes benign thyroid gland neoplasm, hypothyroidism, and acute myeloid leukemia. Example CD7 variants include A2V, G3E, and G3R.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CD7 variants

Examples include A2V, G3E, G3R, G3W, P4A, P5L, R6K, R6T. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.