R83W (p.Arg83Trp) variant of CD7 (T-cell antigen CD7)
R83W (p.Arg83Trp) in CD7 (T-cell antigen CD7) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
R83W (p.Arg83Trp) variant details
- p.Arg83Trp
- cosmic curated COSV53938
- ExAC rs764436785
- TOPMed rs764436785
- gnomAD rs764436785
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.162
- REVEL 0.14
- CADD 15.20
- PolyPhen-2 0.92
- SIFT 0.17
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available