E73K (p.Glu73Lys) variant of CD7 (T-cell antigen CD7)
E73K (p.Glu73Lys) in CD7 (T-cell antigen CD7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
E73K (p.Glu73Lys) variant details
- p.Glu73Lys
- rs769841402
- NCI-TCGA Cosmic COSV9948
- cosmic curated COSV99486
- ExAC rs769841402
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.262
- REVEL 0.17
- CADD 22.80
- PolyPhen-2 0.90
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Ashkenazi Jewish population (allele frequency 0.00029)
- Structural context available