S107L (p.Ser107Leu) variant of CD7 (T-cell antigen CD7)
S107L (p.Ser107Leu) in CD7 (T-cell antigen CD7) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
S107L (p.Ser107Leu) variant details
- p.Ser107Leu
- cosmic curated COSV53940
- ExAC rs758663957
- TOPMed rs758663957
- gnomAD rs758663957
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0965
- REVEL 0.05
- CADD 14.20
- PolyPhen-2 0.15
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available