BCL6 (B-cell lymphoma 6 protein) variants and mutations

BCL6 (also known as B-cell lymphoma 6 protein) is a human protein-coding gene encoding a b-cell lymphoma 6 protein. It temporarily suppresses DNA-damage checkpoints, inflammatory genes, and differentiation programs so germinal-center B cells can proliferate and diversify antibodies. Persistent expression through rearrangement or mutation can drive diffuse large B-cell lymphoma and other lymphoid malignancies. This analysis covers 1,197 BCL6 variants and mutations. Of these, 63% have computational variant effect predictions. Disease context includes diffuse large B-cell lymphoma, neurodegenerative disease, and lymphoid neoplasm. Example BCL6 variants include M1?, A2G, and A2T.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable BCL6 variants

Examples include M1?, A2G, A2T, A2V, S3A, S3L, P4L, P4S. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.