R140H (p.Arg140His) variant of BCL6 (B-cell lymphoma 6 protein)
R140H (p.Arg140His) in BCL6 (B-cell lymphoma 6 protein) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data.
R140H (p.Arg140His) variant details
- p.Arg140His
- rs536118071
- NCI-TCGA Cosmic COSV5165
- cosmic curated COSV51650
- 1000Genomes rs536118071
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.346
- REVEL 0.14
- CADD 22.40
- PolyPhen-2 0.00
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)