R140C (p.Arg140Cys) variant of BCL6 (B-cell lymphoma 6 protein)
R140C (p.Arg140Cys) in BCL6 (B-cell lymphoma 6 protein) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data.
R140C (p.Arg140Cys) variant details
- p.Arg140Cys
- rs779270221
- NCI-TCGA Cosmic COSV5165
- cosmic curated COSV51655
- ExAC rs779270221
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.372
- REVEL 0.16
- CADD 24.70
- PolyPhen-2 0.61
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 3.4e-05)