R26W (p.Arg26Trp) variant of BCL6 (B-cell lymphoma 6 protein)
R26W (p.Arg26Trp) in BCL6 (B-cell lymphoma 6 protein) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data and structural context.
R26W (p.Arg26Trp) variant details
- p.Arg26Trp
- rs779268890
- ClinGen CA2750934
- cosmic curated COSV51655
- ClinVar RCV004093010
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.794
- REVEL 0.85
- CADD 30.00
- PolyPhen-2 1.00
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)
- Structural context available