R28Q (p.Arg28Gln) variant of BCL6 (B-cell lymphoma 6 protein)
R28Q (p.Arg28Gln) in BCL6 (B-cell lymphoma 6 protein) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
R28Q (p.Arg28Gln) variant details
- p.Arg28Gln
- NCI-TCGA Cosmic COSV1043
- cosmic curated COSV10437
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.602
- REVEL 0.46
- CADD 27.60
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available