CD79B (P40259) variants and mutations

CD79B (also known as P40259) is a human protein-coding gene encoding a b-cell antigen receptor complex-associated protein beta chain protein. Together with CD79A, it transduces signals from surface immunoglobulin into B cells through immunoreceptor tyrosine-based activation motifs. Somatic activating mutations are common in certain diffuse large B-cell lymphomas and promote chronic B-cell receptor signaling. This analysis covers 542 CD79B variants and mutations. Of these, 66% have computational variant effect predictions. Disease context includes diffuse large B-cell lymphoma, isolated agammaglobulinemia, and autosomal agammaglobulinemia. Example CD79B variants include M1?, A2G, and R3K.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CD79B variants

Examples include M1?, A2G, R3K, R3S, L4P, L4V, A5V, L6M. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.