R34W (p.Arg34Trp) variant of CD79B (P40259)
R34W (p.Arg34Trp) in CD79B (P40259) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
R34W (p.Arg34Trp) variant details
- p.Arg34Trp
- cosmic curated COSV10799
- TOPMed rs1350196178
- gnomAD rs1350196178
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.172
- REVEL 0.19
- CADD 12.30
- PolyPhen-2 0.08
- SIFT 0.04
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available