UGT2B7 (UDP-glucuronosyltransferase 2B7) variants and mutations

UGT2B7 (also known as UDP-glucuronosyltransferase 2B7) is a human protein-coding gene encoding an UDP-glucuronosyltransferase 2B7 protein. It conjugates glucuronic acid to many drugs and endogenous compounds, including opioids, bile acids, and steroid metabolites, increasing their solubility and elimination. Genetic and physiologic variation can alter clearance of important substrates, although effects are often smaller than for major high-impact pharmacogenes. This analysis covers 1,151 UGT2B7 variants and mutations. Of these, 94% have computational variant effect predictions. Disease context includes response to tramadol, vitamin D deficiency, and COVID-19. Example UGT2B7 variants include S2P, S2Y, and S2T.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable UGT2B7 variants

Examples include S2P, S2Y, S2T, S2S, V3A, V3M, V3L, V3V. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.