S15N (p.Ser15Asn) variant of UGT2B7 (UDP-glucuronosyltransferase 2B7)
S15N (p.Ser15Asn) in UGT2B7 (UDP-glucuronosyltransferase 2B7) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as drug response in the context of Tramadol response. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
S15N (p.Ser15Asn) variant details
- p.Ser15Asn
- rs1577920737
- ClinGen CA357095119
- ClinVar RCV001028163
- Ensembl rs1577920737
- drug response
- Tramadol response
- Missense
- Variant Prioritization Score for Impact Estimate 0.155
- REVEL 0.05
- MetaLR 0.13
- MetaSVM -0.97
- CADD 1.27
- PolyPhen-2 0.03
- SIFT 0.24
- ClinVar: drug response (Tramadol response)
- EBI: Drug response
- UniProt: Drug response
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.7e-05)
- Structural context available