BRD3 (Bromodomain-containing protein 3) variants and mutations

BRD3 (also known as Bromodomain-containing protein 3) is a human protein-coding gene encoding a bromodomain-containing protein 3 protein. It binds acetylated histones and transcription factors to help organize active chromatin and gene expression. Rearrangements involving BRD3 can create oncogenic fusions in rare cancers, and its bromodomains are targeted by BET inhibitors. This analysis covers 1,132 BRD3 variants and mutations. Of these, 75% have computational variant effect predictions. Disease context includes neoplasm, type 2 diabetes mellitus, and substance-related disorder. Example BRD3 variants include S2P, T3P, and A4S.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable BRD3 variants

Examples include S2P, T3P, A4S, A4T, T5M, T6I, A8G, A8S. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.