P149S (p.Pro149Ser) variant of BRD3 (Bromodomain-containing protein 3)
P149S (p.Pro149Ser) in BRD3 (Bromodomain-containing protein 3) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data.
P149S (p.Pro149Ser) variant details
- p.Pro149Ser
- ExAC rs202111048
- gnomAD rs202111048
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.426
- REVEL 0.21
- CADD 20.90
- PolyPhen-2 0.37
- SIFT 0.82
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)