M81V (p.Met81Val) variant of BRD3 (Bromodomain-containing protein 3)
M81V (p.Met81Val) in BRD3 (Bromodomain-containing protein 3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data.
M81V (p.Met81Val) variant details
- p.Met81Val
- rs1056218074
- NCI-TCGA Cosmic COSV5770
- cosmic curated COSV57705
- gnomAD rs1056218074
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.636
- REVEL 0.64
- CADD 25.00
- PolyPhen-2 0.98
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)