GATA3 (P23771) variants and mutations

GATA3 (also known as P23771) is a human protein-coding gene encoding a trans-acting T-cell-specific transcription factor GATA-3 protein. It regulates T-helper-2 differentiation and development of the parathyroids, kidneys, inner ear, and several epithelial tissues. Haploinsufficiency causes HDR syndrome, characterized by hypoparathyroidism, sensorineural deafness, and renal abnormalities. This analysis covers 1,825 GATA3 variants and mutations. Of these, 58% have computational variant effect predictions. Disease context includes hypoparathyroidism-deafness-renal disease syndrome, Hypoparathyroidism - deafness - renal disease, and breast adenocarcinoma. Example GATA3 variants include M1?, E2D, and E2*.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, ClinGen, MaveDB, LitVar.

Notable GATA3 variants

Examples include M1?, E2D, E2*, E2K, E2G, E2V, E2E, V3A. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.