G21R (p.Gly21Arg) variant of GATA3 (P23771)
G21R (p.Gly21Arg) in GATA3 (P23771) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.79 / 1. The record also includes population frequency data and structural context.
G21R (p.Gly21Arg) variant details
- p.Gly21Arg
- NCI-TCGA TCGA novel
- Ensembl rs2131482429
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.787
- REVEL 0.75
- MetaLR 0.89
- MetaSVM 0.94
- CADD 26.90
- PolyPhen-2 0.67
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available