CALCA (P06881) variants and mutations

CALCA (also known as P06881) is a human protein-coding gene encoding a calcitonin gene-related peptide 1 protein. CGRP1 is a secreted peptide hormone that widens blood vessels through the CALCRL-RAMP1 receptor complex. CGRP1 is also abundant in the nervous system, where it can act as a neurotransmitter or neuromodulator. This analysis covers 404 CALCA variants and mutations. Of these, 86% have computational variant effect predictions. Disease context includes migraine disorder, AL amyloidosis, and hyperprolactinemia. Example CALCA variants include M1R, G2R, and G2S.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CALCA variants

Examples include M1R, G2R, G2S, G2A, G2G, G2D, F3L, Q4H. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.