IL15RA (Q13261) variants and mutations

IL15RA (also known as Q13261) is a human protein-coding gene encoding an interleukin-15 receptor subunit alpha protein. It binds IL-15 with high affinity and presents it to neighboring lymphocytes, supporting natural-killer-cell and memory CD8 T-cell development and survival. Disrupted signaling can impair cytotoxic lymphocyte homeostasis, while pathway activation is being exploited therapeutically in cancer immunology. This analysis covers 557 IL15RA variants and mutations. Of these, 82% have computational variant effect predictions. Disease context includes neuroblastoma, non-small cell lung carcinoma, and Sepsis. Example IL15RA variants include A2T, A2V, and P3L.

Variant analysis overview

Gene: IL15RA
Protein: Q13261
UniProt accession: Q13261
Organism: Homo sapiens
Variants analyzed: 557
Variant scope: all variants
Completed: 2026-08-20

Variant and mutation evidence

Variant composition: 360 unspecified-consequence records; 10 stop lost; 2 stop retained variant; 120 missense variants; 34 synonymous variants; 10 stop-gained variants; 13 frameshift variants; 1 in-frame insertions; 5 in-frame deletions; 1 splice-region variants; 1 substitution
Prediction scores: 458 variants have prediction scores (82% of the analyzed set).

Clinical, disease, and population context

Disease context: 25 disease associations are represented. Top associations: neuroblastoma, non-small cell lung carcinoma, Sepsis, alcohol drinking, acute respiratory distress syndrome, arthropathy, neoplasm, cancer, acute myeloid leukemia, prostate cancer, immunodeficiency 128, glioblastoma.

Protein structure and variant hotspots

Protein features: 1 transmembrane segments; 1 domains; 1 post-translational modification sites.
Structural context: 121 variants have structural context.
PTM context: 3 variants overlap post-translational modification sites.

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable IL15RA variants

Examples include A2T, A2V, P3L, P3S, R4Q, R5P, R5Q, A6P. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.

IL15RA analysis run — IL15RA (557 variants) — completed 2026-08-20