A105V (p.Ala105Val) variant of IL15RA (Q13261)
A105V (p.Ala105Val) in IL15RA (Q13261) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
A105V (p.Ala105Val) variant details
- p.Ala105Val
- cosmic curated COSV66093
- ESP rs143835821
- ExAC rs143835821
- gnomAD rs143835821
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.169
- REVEL 0.04
- CADD 6.30
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the South Asian population (allele frequency 1.4e-05)
- Structural context available