C59Y (p.Cys59Tyr) variant of IL15RA (Q13261)
C59Y (p.Cys59Tyr) in IL15RA (Q13261) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.83 / 1. The record also includes population frequency data and structural context.
C59Y (p.Cys59Tyr) variant details
- p.Cys59Tyr
- cosmic curated COSV66092
- ExAC rs774050503
- TOPMed rs774050503
- gnomAD rs774050503
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.828
- REVEL 0.87
- CADD 24.50
- PolyPhen-2 1.00
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available