T69M (p.Thr69Met) variant of IL15RA (Q13261)
T69M (p.Thr69Met) in IL15RA (Q13261) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
T69M (p.Thr69Met) variant details
- p.Thr69Met
- rs752103406
- NCI-TCGA Cosmic COSV6609
- cosmic curated COSV66092
- ExAC rs752103406
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.459
- REVEL 0.23
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available