CALCB (P10092) variants and mutations

CALCB (also known as P10092) is a human protein-coding gene encoding a calcitonin gene-related peptide 2 protein. CGRP2 is a secreted peptide that activates the CALCRL-RAMP1 receptor complex. Like CGRP1, it promotes blood-vessel dilation and may contribute to signaling in the central nervous system. This analysis covers 358 CALCB variants and mutations. Of these, 84% have computational variant effect predictions. Disease context includes migraine disorder, Increased circulating prolactin concentration, and hyperprolactinemia. Example CALCB variants include G2A, G2S, and G2G.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CALCB variants

Examples include G2A, G2S, G2G, G2R, G2D, F3Y, F3S, F3F. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.