AURKB (Aurora kinase B) variants and mutations

AURKB (also known as Aurora kinase B) is a human protein-coding gene encoding an aurora kinase B protein. It controls chromosome alignment, kinetochore-microtubule attachment, the spindle checkpoint, and cytokinesis as part of the chromosomal passenger complex. Excess activity is common in proliferative cancers and can contribute to aneuploidy and treatment resistance. This analysis covers 796 AURKB variants and mutations. Of these, 67% have computational variant effect predictions. Disease context includes neurodegenerative disease, Alzheimer disease, and Parkinson disease. Example AURKB variants include A2S, A2T, and A2V.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable AURKB variants

Examples include A2S, A2T, A2V, Q3*, E5D, E5V, N6I, N6S. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.