I74T (p.Ile74Thr) variant of AURKB (Aurora kinase B)
I74T (p.Ile74Thr) in AURKB (Aurora kinase B) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
I74T (p.Ile74Thr) variant details
- p.Ile74Thr
- ExAC rs763420999
- TOPMed rs763420999
- gnomAD rs763420999
- Missense
- Variant Prioritization Score for Impact Estimate 0.615
- CADD 26.40
- PolyPhen-2 0.08
- SIFT 0.02
- Most common in the HGDP:BALOCHI population (allele frequency 0.022)
- Structural context available