R81C (p.Arg81Cys) variant of AURKB (Aurora kinase B)
R81C (p.Arg81Cys) in AURKB (Aurora kinase B) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
R81C (p.Arg81Cys) variant details
- p.Arg81Cys
- rs752234429
- ExAC rs752234429
- TOPMed rs752234429
- gnomAD rs752234429
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.699
- CADD 32.00
- PolyPhen-2 0.17
- SIFT 0.02
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 7.6e-05)
- Structural context available