PRKCH (Protein kinase C eta type) variants and mutations
PRKCH (also known as Protein kinase C eta type) is a human protein-coding gene encoding a protein kinase C eta type protein. Its annotated function is calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial…. It is annotated at the cytoplasm. This analysis covers 861 PRKCH variants and mutations. Of these, 97% have computational variant effect predictions. Disease context includes obesity disorder, intervertebral disk degenerative disorder, and androgenetic alopecia. Example PRKCH variants include S2L, S2*, and S2W.
Variant analysis overview
- Gene: PRKCH
- Protein: Protein kinase C eta type
- UniProt accession: P24723
- Organism: Homo sapiens
- Variants analyzed: 861
- Variant scope: all variants
- Completed: 2026-10-31
Variant and mutation evidence
- Variant composition: 648 unspecified-consequence records; 8 stop-gained variants; 151 missense variants; 91 synonymous variants; 1 in-frame insertions; 16 frameshift variants; 7 in-frame deletions; 2 splice-region variants
- Prediction scores: 838 variants have prediction scores (97% of the analyzed set).
Clinical, disease, and population context
- Disease context: 11 disease associations are represented. Top associations: obesity disorder, intervertebral disk degenerative disorder, androgenetic alopecia, diabetes mellitus, prostate carcinoma, alcohol drinking, urolithiasis, benign prostatic hyperplasia, atrial fibrillation, adolescent idiopathic scoliosis, deficiency anemia.
Protein structure and variant hotspots
- Protein features: 3 domains; 2 binding sites; 6 post-translational modification sites.
- Structural context: 618 variants have structural context.
- PTM context: 9 variants overlap post-translational modification sites.
Data sources
Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, Open Targets, MaveDB, LitVar.
Notable PRKCH variants
Examples include S2L, S2*, S2W, S2S, S3P, S3Y, S3S, S3C. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.
- S2L (p.Ser2Leu), TOPMed rs958832530, gnomAD rs958832530, REVEL 0.07, ESM-1b 0.89
- S2* (p.Ser2Ter), gnomAD 14-61322106-C-A, CADD 38.00
- S2W (p.Ser2Trp), gnomAD 14-61322106-C-G, REVEL 0.09, ESM-1b 1.00
- S2S (p.Ser2Ser), gnomAD 14-61322107-G-A, CADD 14.60
- S3P (p.Ser3Pro), gnomAD rs1175984995, REVEL 0.13, ESM-1b 0.00
- S3Y (p.Ser3Tyr), gnomAD 14-61322109-C-A, REVEL 0.09, ESM-1b 0.58
- S3S (p.Ser3Ser), rs866830738, gnomAD 14-61322110-T-C, CADD 13.10
- S3C (p.Ser3Cys), gnomAD 14-61326999-A-T, REVEL 0.05, ESM-1b 0.18
- S3R (p.Ser3Arg), rs1194092550, gnomAD 14-61326999-A-C, REVEL 0.06, ESM-1b 0.00
- S3I (p.Ser3Ile), gnomAD 14-61327000-G-T, REVEL 0.05, ESM-1b 0.08
- G4S (p.Gly4Ser), Ensembl rs1196220004, ESM-1b 0.00, AlphaMissense 0.08
- G4C (p.Gly4Cys), gnomAD 14-61322111-G-T, REVEL 0.06, ESM-1b 0.00
- G4V (p.Gly4Val), gnomAD 14-61322112-G-T, REVEL 0.04, ESM-1b 0.00
- G4G (p.Gly4Gly), rs1479681741, gnomAD 14-61322113-C-T, CADD 13.40
- T5A (p.Thr5Ala), ExAC rs765167007, gnomAD rs765167007, REVEL 0.07, ESM-1b 0.00
- T5I (p.Thr5Ile), gnomAD rs1306661027, REVEL 0.08, ESM-1b 0.00
- T5N (p.Thr5Asn), gnomAD 14-61322115-C-A, REVEL 0.12, ESM-1b 0.00
- T5T (p.Thr5Thr), gnomAD 14-61322116-C-A, CADD 12.00
- M6V (p.Met6Val), TOPMed rs2045633420, ESM-1b 0.00, AlphaMissense 0.11
- p.Met6 Lys7insProGlyThrMet, gnomAD 14-61322108-T-TCT, CADD 21.00
- M6T (p.Met6Thr), gnomAD 14-61322118-T-C, REVEL 0.20, ESM-1b 0.00
- M6R (p.Met6Arg), gnomAD 14-61322118-T-G, REVEL 0.30, ESM-1b 0.00
- M6K (p.Met6Lys), gnomAD 14-61322118-T-A, REVEL 0.29, ESM-1b 0.00
- M6L (p.Met6Leu), rs1019611219, gnomAD 14-61327011-A-T, REVEL 0.10, ESM-1b 0.00
- K7N (p.Lys7Asn), TOPMed rs1443653480, gnomAD rs1443653480, REVEL 0.08, ESM-1b 0.07
- K7R (p.Lys7Arg), TOPMed rs1348096883, gnomAD rs1348096883, REVEL 0.06, ESM-1b 0.00
- K7E (p.Lys7Glu), gnomAD 14-61322120-A-G, REVEL 0.11, ESM-1b 0.99
- K7I (p.Lys7Ile), gnomAD 14-61327048-A-T, REVEL 0.17, ESM-1b 0.00
- F8L (p.Phe8Leu), gnomAD rs1279626139, REVEL 0.34, ESM-1b 0.84
- F8F (p.Phe8Phe), gnomAD 14-61322125-C-T, CADD 14.50
- N9S (p.Asn9Ser), rs371540089, ESP rs371540089, ExAC rs371540089, TOPMed rs371540089, REVEL 0.10, ESM-1b 0.00, Variant assessed as somatic; moderate impact.
- N9D (p.Asn9Asp), gnomAD 14-61322126-A-G, REVEL 0.11, ESM-1b 0.00
- N9N (p.Asn9Asn), gnomAD 14-61322128-T-C, CADD 13.40
- G10D (p.Gly10Asp), gnomAD 14-61322130-G-A, REVEL 0.55, ESM-1b 1.00
- G10V (p.Gly10Val), gnomAD 14-61322130-G-T, REVEL 0.56, ESM-1b 1.00
- G10G (p.Gly10Gly), rs1217091931, gnomAD 14-61322131-C-G, CADD 11.60
- G10E (p.Gly10Glu), gnomAD 14-61327015-G-A, REVEL 0.06, ESM-1b 1.00
- Y11C (p.Tyr11Cys), ExAC rs763038774, TOPMed rs763038774, gnomAD rs763038774, REVEL 0.13, ESM-1b 0.00
- L12S (p.Leu12Ser), gnomAD 14-61322136-T-C, REVEL 0.45, ESM-1b 1.00
- L12L (p.Leu12Leu), rs1204378051, gnomAD 14-61322137-G-A, CADD 14.00
- L12P (p.Leu12Pro), rs1447887296, gnomAD 14-61327028-GCTGG, CADD 16.40
- L12M (p.Leu12Met), gnomAD 14-61327029-C-A, REVEL 0.04, ESM-1b 1.00
- R13S (p.Arg13Ser), 1000Genomes rs557606070, ExAC rs557606070, TOPMed rs557606070, gnomAD rs557606070, REVEL 0.29, ESM-1b 1.00
- R13G (p.Arg13Gly), gnomAD 14-61322138-A-G, REVEL 0.48, ESM-1b 1.00
- R13K (p.Arg13Lys), gnomAD 14-61322139-G-A, REVEL 0.17, ESM-1b 0.00
- R13M (p.Arg13Met), gnomAD 14-61322139-G-T, REVEL 0.55, ESM-1b 1.00
- V14A (p.Val14Ala), Ensembl rs2045633889, ESM-1b 1.00, AlphaMissense 0.81
- V14I (p.Val14Ile), gnomAD 14-61322141-G-A, REVEL 0.08, ESM-1b 0.00
- V14V (p.Val14Val), gnomAD 14-61322143-C-G, CADD 12.50
- R15L (p.Arg15Leu), TOPMed rs1182708761, gnomAD rs1182708761, REVEL 0.57, ESM-1b 1.00
- R15P (p.Arg15Pro), TOPMed rs1182708761, gnomAD rs1182708761, REVEL 0.57, ESM-1b 1.00
- R15C (p.Arg15Cys), gnomAD 14-61322144-C-T, REVEL 0.65, ESM-1b 1.00
- R15G (p.Arg15Gly), gnomAD 14-61322144-C-G, REVEL 0.59, ESM-1b 1.00
- R15S (p.Arg15Ser), gnomAD 14-61322144-C-A, REVEL 0.47, ESM-1b 1.00
- R15H (p.Arg15His), gnomAD 14-61322145-G-A, REVEL 0.35, ESM-1b 1.00
- R15R (p.Arg15Arg), gnomAD 14-61322146-C-A, CADD 12.60
- I16F (p.Ile16Phe), gnomAD rs2045634077, REVEL 0.26, ESM-1b 0.00
- I16T (p.Ile16Thr), TOPMed rs1201894343, gnomAD rs1201894343, REVEL 0.41, ESM-1b 1.00
- I16I (p.Ile16Ile), rs1246191845, gnomAD 14-61322149-C-A, CADD 12.70
- G17A (p.Gly17Ala), gnomAD rs1195704186, REVEL 0.26, ESM-1b 0.00
- G17C (p.Gly17Cys), 1000Genomes rs138654844, ExAC rs138654844, gnomAD rs138654844, REVEL 0.33, ESM-1b 0.00
- G17S (p.Gly17Ser), gnomAD 14-61322150-G-A, REVEL 0.35, ESM-1b 0.00
- G17D (p.Gly17Asp), gnomAD 14-61322151-G-A, REVEL 0.35, ESM-1b 0.00
- E18E (p.Glu18Glu), gnomAD 14-61322155-G-A, CADD 13.30
- E18* (p.Glu18Ter), gnomAD 14-61327023-G-T, CADD 11.50
- E18D (p.Glu18Asp), rs572193605, gnomAD 14-61327028-G-T, REVEL 0.09, ESM-1b 1.00
- A19S (p.Ala19Ser), ExAC rs755012009, TOPMed rs755012009, gnomAD rs755012009, REVEL 0.47, ESM-1b 1.00
- A19T (p.Ala19Thr), ExAC rs755012009, TOPMed rs755012009, gnomAD rs755012009, REVEL 0.53, ESM-1b 1.00
- A19V (p.Ala19Val), rs55645551, UniProt VAR 042312, 1000Genomes rs55645551, ESP rs55645551, REVEL 0.34, ESM-1b 1.00, Likely benign, PRKCH-related disorder
- A19E (p.Ala19Glu), gnomAD 14-61322157-C-A, REVEL 0.50, ESM-1b 1.00
- A19A (p.Ala19Ala), gnomAD 14-61327004-T-C, CADD 3.73
- A19G (p.Ala19Gly), rs1457423603, gnomAD 14-61327036-C-G, REVEL 0.27, ESM-1b 0.14
- A19D (p.Ala19Asp), gnomAD 14-61327036-C-A, REVEL 0.14, ESM-1b 1.00
- V20L (p.Val20Leu), ExAC rs752215620, gnomAD rs752215620, ESM-1b 0.00, AlphaMissense 0.17
- V20M (p.Val20Met), gnomAD 14-61322159-G-A, REVEL 0.25, ESM-1b 0.00
- V20V (p.Val20Val), gnomAD 14-61322161-G-T, CADD 13.20
- G21R (p.Gly21Arg), ExAC rs755653210, gnomAD rs755653210, REVEL 0.14, ESM-1b 0.72
- G21W (p.Gly21Trp), gnomAD 14-61322162-G-T, REVEL 0.26, ESM-1b 1.00
- G21G (p.Gly21Gly), gnomAD 14-61322164-G-T, CADD 14.30
- G21E (p.Gly21Glu), gnomAD 14-61327066-CA-C, CADD 17.50
- G21V (p.Gly21Val), rs1232213266, gnomAD 14-61327069-G-T, REVEL 0.17, ESM-1b 1.00
- L22L (p.Leu22Leu), rs1329970573, gnomAD 14-61322165-C-T, CADD 14.20
- L22F (p.Leu22Phe), rs1216862492, gnomAD 14-61327053-C-T, REVEL 0.23, ESM-1b 1.00
- L22P (p.Leu22Pro), rs2045707089, gnomAD 14-61327054-T-C, REVEL 0.25, ESM-1b 1.00
- Q23L (p.Gln23Leu), gnomAD 14-61322169-A-T, REVEL 0.31, ESM-1b 0.57
- Q23Q (p.Gln23Gln), rs1438298916, gnomAD 14-61322170-G-A, CADD 13.10
- Q23* (p.Gln23Ter), gnomAD 14-61326996-C-T, CADD 8.85
- Q23P (p.Gln23Pro), rs2045705890, gnomAD 14-61326997-A-C, REVEL 0.12, ESM-1b 1.00
- Q23H (p.Gln23His), rs2045705929, gnomAD 14-61326998-G-C, REVEL 0.14, ESM-1b 0.00
- Q23R (p.Gln23Arg), gnomAD 14-61327013-GGGGA, CADD 10.20
- P24P (p.Pro24Pro), gnomAD 14-61322173-C-T, CADD 14.90
- P24L (p.Pro24Leu), gnomAD 14-61327059-GCC-G, CADD 15.20
- P24T (p.Pro24Thr), gnomAD 14-61327062-C-A, REVEL 0.11, ESM-1b 1.00
- P24H (p.Pro24His), gnomAD 14-61327063-C-A, REVEL 0.16, ESM-1b 1.00
- T25I (p.Thr25Ile), 1000Genomes rs553588998, ExAC rs553588998, TOPMed rs553588998, gnomAD rs553588998, REVEL 0.68, ESM-1b 1.00
- T25P (p.Thr25Pro), gnomAD rs1305111487, REVEL 0.62, ESM-1b 1.00
- T25T (p.Thr25Thr), rs1227312933, gnomAD 14-61322176-C-T, CADD 13.40
- R26C (p.Arg26Cys), 1000Genomes rs574074666, ExAC rs574074666, gnomAD rs574074666, REVEL 0.44, ESM-1b 0.00
- R26H (p.Arg26His), ExAC rs756874616, TOPMed rs756874616, gnomAD rs756874616, REVEL 0.23, ESM-1b 0.00, Uncertain significance, not specified
- R26L (p.Arg26Leu), ExAC rs756874616, TOPMed rs756874616, gnomAD rs756874616, REVEL 0.25, ESM-1b 0.00
- R26A (p.Arg26Ala), gnomAD 14-61322174-AC-A, CADD 27.50
- R26S (p.Arg26Ser), gnomAD 14-61322177-C-A, REVEL 0.20, ESM-1b 0.00
- R26R (p.Arg26Arg), rs2045635009, gnomAD 14-61322179-C-G, CADD 14.50
- R26G (p.Arg26Gly), rs1247254370, gnomAD 14-61327071-A-G, REVEL 0.17, ESM-1b 0.00
- W27R (p.Trp27Arg), TOPMed rs1370080348, ESM-1b 1.00, AlphaMissense 0.90
- W27L (p.Trp27Leu), gnomAD 14-61322181-G-T, REVEL 0.23, ESM-1b 0.84
- W27C (p.Trp27Cys), gnomAD 14-61322182-G-T, REVEL 0.27, ESM-1b 0.26
- W27S (p.Trp27Ser), rs1015891335, gnomAD 14-61327045-G-C, REVEL 0.14, ESM-1b 0.62
- W27G (p.Trp27Gly), gnomAD 14-61327145-GC-G, CADD 1.43
- W27* (p.Trp27Ter), rs1462188418, gnomAD 14-61327151-G-A, CADD 2.06
- S28P (p.Ser28Pro), gnomAD rs1196284150, ESM-1b 1.00, AlphaMissense 0.85
- S28S (p.Ser28Ser), rs1441882518, gnomAD 14-61327043-A-G, CADD 19.90
- S28* (p.Ser28Ter), rs2140122354, gnomAD 14-61327066-C-G, CADD 17.27
- L29L (p.Leu29Leu), gnomAD 14-61322186-C-T, CADD 13.60
- R30C (p.Arg30Cys), TOPMed rs2045635168, ESM-1b 1.00, AlphaMissense 0.70
- R30H (p.Arg30His), gnomAD rs1449901545, REVEL 0.42, ESM-1b 1.00
- R30P (p.Arg30Pro), gnomAD 14-61322190-G-C, REVEL 0.45, ESM-1b 1.00
- R30R (p.Arg30Arg), gnomAD 14-61322191-C-T, CADD 14.30
- R30S (p.Arg30Ser), rs1484746662, gnomAD 14-61327091-G-C, REVEL 0.09, ESM-1b 1.00
- H31P (p.His31Pro), Ensembl rs1594910673, ESM-1b 1.00, AlphaMissense 0.35
- H31L (p.His31Leu), gnomAD 14-61322193-A-T, REVEL 0.30, ESM-1b 1.00
- H31H (p.His31His), rs199727888, gnomAD 14-61322194-C-T, CADD 13.60
- S32L (p.Ser32Leu), rs1253785238, TOPMed rs1253785238, gnomAD rs1253785238, REVEL 0.16, ESM-1b 1.00, Variant assessed as somatic; moderate impact.
- S32P (p.Ser32Pro), Ensembl rs1054017071, REVEL 0.16, ESM-1b 1.00
- S32S (p.Ser32Ser), gnomAD 14-61322197-G-A, CADD 13.10
- L33R (p.Leu33Arg), ExAC rs747362339, gnomAD rs747362339, REVEL 0.07, ESM-1b 1.00
- L33V (p.Leu33Val), Ensembl rs2140117050, ESM-1b 0.00, AlphaMissense 0.07
- L33F (p.Leu33Phe), gnomAD 14-61322198-C-T, REVEL 0.03, ESM-1b 0.00
- L33L (p.Leu33Leu), rs769218523, gnomAD 14-61322200-C-T, CADD 12.50
- F34F (p.Phe34Phe), rs777131452, gnomAD 14-61322203-C-T, CADD 15.40
- F34S (p.Phe34Ser), rs936577453, gnomAD 14-61327105-T-C, REVEL 0.14, ESM-1b 0.00
- K35R (p.Lys35Arg), ExAC rs748549094, gnomAD rs748549094, REVEL 0.13, ESM-1b 0.00
- K35N (p.Lys35Asn), rs1270724232, gnomAD 14-61327076-G-C, REVEL 0.17, ESM-1b 0.00
- K36E (p.Lys36Glu), Ensembl rs2045635602, ESM-1b 0.00, AlphaMissense 0.20
- K36R (p.Lys36Arg), rs1805626087, ClinGen CA390094362, ClinVar RCV004515151, TOPMed rs1805626087, REVEL 0.20, ESM-1b 0.00, Uncertain significance, not specified
- K45del (p.Lys45del), gnomAD 14-61327123-CGAA-, CADD 11.00
- K36N (p.Lys36Asn), gnomAD 14-61327127-G-T, REVEL 0.25, ESM-1b 0.00
- G37G (p.Gly37Gly), rs769941826, gnomAD 14-61322212-C-T, CADD 13.80
- G37C (p.Gly37Cys), rs932248801, gnomAD 14-61327086-G-T, REVEL 0.22, ESM-1b 0.00
- G37D (p.Gly37Asp), rs1241326555, gnomAD 14-61327087-G-A, REVEL 0.31, ESM-1b 0.00
- G37V (p.Gly37Val), gnomAD 14-61327109-TG-T, CADD 12.00
- H38D (p.His38Asp), gnomAD 14-61322213-C-G, REVEL 0.10, ESM-1b 0.00
- H38Y (p.His38Tyr), gnomAD 14-61322213-C-T, REVEL 0.12, ESM-1b 0.00
- H38Q (p.His38Gln), gnomAD 14-61322215-C-A, REVEL 0.16, ESM-1b 0.00
- Q39R (p.Gln39Arg), Ensembl rs2045635713, REVEL 0.14, ESM-1b 0.00
- L40V (p.Leu40Val), rs372517762, ClinGen CA7214989, ClinVar RCV004515152, ESP rs372517762, REVEL 0.10, ESM-1b 0.00, Uncertain significance, not specified
- L40L (p.Leu40Leu), rs372517762, gnomAD 14-61322219-C-T, CADD 14.50
- L41L (p.Leu41Leu), rs2045635889, gnomAD 14-61322222-C-T, CADD 14.10
- D42A (p.Asp42Ala), Ensembl rs2140117100, ESM-1b 1.00, AlphaMissense 0.87
- D42E (p.Asp42Glu), gnomAD 14-61322227-C-G, REVEL 0.32, ESM-1b 1.00
- D42D (p.Asp42Asp), rs563007662, gnomAD 14-61322227-C-T, CADD 12.60
- D42K (p.Asp42Lys), rs1566821933, gnomAD 14-61327046-G-GAA, CADD 18.10
- D42H (p.Asp42His), gnomAD 14-61327050-G-C, REVEL 0.32, ESM-1b 1.00
- D42Y (p.Asp42Tyr), gnomAD 14-61327050-G-T, REVEL 0.42, ESM-1b 1.00
- D42G (p.Asp42Gly), gnomAD 14-61327078-A-G, REVEL 0.18, ESM-1b 1.00
- P43L (p.Pro43Leu), gnomAD 14-61322229-C-T, REVEL 0.73, ESM-1b 1.00
- P43P (p.Pro43Pro), gnomAD 14-61322230-C-G, CADD 14.70
- P43Q (p.Pro43Gln), gnomAD 14-61327093-TC-T, CADD 16.90
- P43A (p.Pro43Ala), rs377056504, gnomAD 14-61327146-C-G, REVEL 0.16, ESM-1b 0.00
- P43H (p.Pro43His), gnomAD 14-61327147-C-A, REVEL 0.08, ESM-1b 1.00
- Y44C (p.Tyr44Cys), gnomAD 14-61322232-A-G, REVEL 0.86, ESM-1b 1.00
- Y44Y (p.Tyr44Tyr), rs2045635983, gnomAD 14-61322233-T-C, CADD 11.90
- L45V (p.Leu45Val), TOPMed rs1458261811, gnomAD rs1458261811, ESM-1b 0.00, AlphaMissense 0.05
- L45P (p.Leu45Pro), gnomAD 14-61322235-T-C, REVEL 0.28, ESM-1b 1.00
- L45Q (p.Leu45Gln), gnomAD 14-61322235-T-A, REVEL 0.32, ESM-1b 1.00
- L45W (p.Leu45Trp), gnomAD 14-61327132-T-G, REVEL 0.06, ESM-1b 1.00
- L45L (p.Leu45Leu), rs1413441004, gnomAD 14-61327175-C-T, CADD 6.64
- T46M (p.Thr46Met), gnomAD 14-61322238-C-T, REVEL 0.18, ESM-1b 1.00
- T46T (p.Thr46Thr), rs1162933752, gnomAD 14-61327130-A-G, CADD 7.60
- V47G (p.Val47Gly), Ensembl rs2140117122, ESM-1b 1.00, AlphaMissense 0.93
- S48R (p.Ser48Arg), TOPMed rs923637190, ESM-1b 0.00, AlphaMissense 0.72
- S48N (p.Ser48Asn), gnomAD 14-61322244-G-A, REVEL 0.14, ESM-1b 0.00
- S48S (p.Ser48Ser), rs923637190, gnomAD 14-61322245-C-T, CADD 15.30
- p.Val49 Asp50del, gnomAD 14-61322244-GCGTG, CADD 22.60
- D50D (p.Asp50Asp), rs576321769, gnomAD 14-61322251-C-T, CADD 14.50
- Q51H (p.Gln51His), rs2504035534, ClinGen CA390094463, ClinVar RCV004515156, ESM-1b 0.00, AlphaMissense 0.14, Uncertain significance, not specified
- Q51R (p.Gln51Arg), gnomAD 14-61322253-A-G, REVEL 0.20, ESM-1b 0.00
- V52L (p.Val52Leu), ESP rs148375974, ExAC rs148375974, TOPMed rs148375974, gnomAD rs148375974, REVEL 0.08, ESM-1b 0.00
- V52M (p.Val52Met), ESP rs148375974, ExAC rs148375974, TOPMed rs148375974, gnomAD rs148375974, REVEL 0.17, ESM-1b 0.02
- p.Val52 Gln56del, rs1177330807, gnomAD 14-61322250-ACCAG, CADD 22.50
Public PRKCH analysis runs
- PRKCH analysis run — PRKCH (861 variants) — completed 2026-10-31