JUN (Transcription factor Jun) variants and mutations

JUN (also known as Transcription factor Jun) is a human protein-coding gene encoding a transcription factor protein. Together with FOS-family partners, it forms AP-1 transcriptional complexes that convert stress, cytokine, and growth-factor signals into changes in proliferation, differentiation, and inflammation. Persistent activation can support tumor growth and inflammatory disease. This analysis covers 1,148 JUN variants and mutations. Of these, 86% have computational variant effect predictions. Disease context includes neurodegenerative disease, cancer, and Alzheimer disease. Example JUN variants include T2I, A3T, and A3V.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable JUN variants

Examples include T2I, A3T, A3V, A3A, K4G, K4K, K4N, M5T. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.