S17L (p.Ser17Leu) variant of JUN (Transcription factor Jun)
S17L (p.Ser17Leu) in JUN (Transcription factor Jun) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
S17L (p.Ser17Leu) variant details
- p.Ser17Leu
- rs749502446
- NCI-TCGA Cosmic COSV6466
- ExAC rs749502446
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.354
- REVEL 0.09
- CADD 23.20
- PolyPhen-2 0.10
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available