GNA13 (Q14344) variants and mutations

GNA13 (also known as Q14344) is a human protein-coding gene encoding a guanine nucleotide-binding protein subunit alpha-13 protein. It couples selected receptors to Rho-family signaling, controlling cytoskeletal organization, migration, and lymphocyte positioning. Somatic loss-of-function variants are recurrent in germinal-center B-cell lymphomas and can disrupt normal confinement of B cells within lymphoid follicles. This analysis covers 641 GNA13 variants and mutations. Of these, 95% have computational variant effect predictions. Disease context includes lymphoma, neurodegenerative disease, and diffuse large B-cell lymphoma. Example GNA13 variants include A2V, P6L, and P6S.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable GNA13 variants

Examples include A2V, P6L, P6S, S7*, S7L, R8G, R8L, R8W. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.