R8W (p.Arg8Trp) variant of GNA13 (Q14344)
R8W (p.Arg8Trp) in GNA13 (Q14344) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.67 / 1. The record also includes population frequency data and structural context.
R8W (p.Arg8Trp) variant details
- p.Arg8Trp
- NCI-TCGA Cosmic COSV7147
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.67
- REVEL 0.63
- MetaLR 0.61
- MetaSVM 0.18
- CADD 32.00
- PolyPhen-2 0.75
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available