L40I (p.Leu40Ile) variant of VCL (Vinculin)
L40I (p.Leu40Ile) in VCL (Vinculin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L40I (p.Leu40Ile) variant details
- p.Leu40Ile
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.455
- REVEL 0.21
- CADD 27.20
- PolyPhen-2 0.92
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available