D33Y (p.Asp33Tyr) variant of VCL (Vinculin)
D33Y (p.Asp33Tyr) in VCL (Vinculin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
D33Y (p.Asp33Tyr) variant details
- p.Asp33Tyr
- gnomAD 10-73998304-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.658
- REVEL 0.54
- CADD 32.00
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available
- Literature evidence available