G146R (p.Gly146Arg) variant of TUBB2B (Tubulin beta-2B chain)
G146R (p.Gly146Arg) in TUBB2B (Tubulin beta-2B chain) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.80 / 1. The record also includes population frequency data and structural context.
G146R (p.Gly146Arg) variant details
- p.Gly146Arg
- NCI-TCGA Cosmic COSV9945
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.799
- REVEL 0.96
- AlphaMissense 1.00
- MetaLR 0.50
- MetaSVM 0.14
- CADD 26.60
- PolyPhen-2 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available