V31L (p.Val31Leu) variant of TP53 (Cellular tumor antigen p53)
V31L (p.Val31Leu) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from EBI and UniProt describe it as benign in the context of in sporadic cancers. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes experimental measurements and structural context.
V31L (p.Val31Leu) variant details
- p.Val31Leu
- 1000Genomes rs201753350
- ExAC rs201753350
- TOPMed rs201753350
- gnomAD rs201753350
- Benign
- in sporadic cancers
- Missense
- Variant Prioritization Score for Impact Estimate 0.269
- ESM-1b 0.00
- AlphaMissense 0.09
- EBI: Benign (in sporadic cancers)
- UniProt: Benign (in sporadic cancers)
- Structural context available
- p53 variant effect measured by cell growth: score 0.465