S6P (p.Ser6Pro) variant of TP53 (Cellular tumor antigen p53)
S6P (p.Ser6Pro) in TP53 (Cellular tumor antigen p53) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, experimental measurements, and structural context.
S6P (p.Ser6Pro) variant details
- p.Ser6Pro
- gnomAD rs1357147493
- Missense
- Variant Prioritization Score for Impact Estimate 0.484
- REVEL 0.59
- ESM-1b 0.00
- AlphaMissense 0.08
- CADD 15.00
- PolyPhen-2 0.70
- SIFT 0.14
- Most common in the 1KG:YRI population (allele frequency 0.0043)
- Structural context available
- p53 variant effect measured by cell growth: score 0.449