S33C (p.Ser33Cys) variant of TP53 (Cellular tumor antigen p53)
S33C (p.Ser33Cys) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from EBI and UniProt describe it as likely benign in the context of in a sporadic cancer. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes experimental measurements and structural context.
S33C (p.Ser33Cys) variant details
- p.Ser33Cys
- Ensembl rs1555526832
- Likely benign
- in a sporadic cancer
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- ESM-1b 0.00
- AlphaMissense 0.09
- EBI: Likely benign (in a sporadic cancer)
- UniProt: Likely benign (in a sporadic cancer)
- Structural context available
- p53 variant effect measured by cell growth: score 0.715