S15N (p.Ser15Asn) variant of TP53 (Cellular tumor antigen p53)
S15N (p.Ser15Asn) in TP53 (Cellular tumor antigen p53) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, experimental measurements, and structural context.
S15N (p.Ser15Asn) variant details
- p.Ser15Asn
- TOPMed rs2073520420
- gnomAD rs2073520420
- Missense
- Variant Prioritization Score for Impact Estimate 0.657
- REVEL 0.71
- ESM-1b 0.00
- AlphaMissense 0.81
- CADD 24.10
- Most common in the 1KG:CHB population (allele frequency 0.015)
- Structural context available
- p53 variant effect measured by cell growth: score -2.99