S15C (p.Ser15Cys) variant of TP53 (Cellular tumor antigen p53)
S15C (p.Ser15Cys) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance in the context of in a sporadic cancer. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes experimental measurements and structural context.
S15C (p.Ser15Cys) variant details
- p.Ser15Cys
- Ensembl rs2073520545
- Uncertain significance
- in a sporadic cancer
- Missense
- Variant Prioritization Score for Impact Estimate 0.233
- ESM-1b 0.00
- AlphaMissense 0.45
- EBI: Variant of uncertain significance (in a sporadic cancer)
- UniProt: Uncertain significance (in a sporadic cancer)
- Structural context available
- p53 variant effect measured by cell growth: score -2.99