R158P (p.Arg158Pro) variant of TP53 (Cellular tumor antigen p53)
R158P (p.Arg158Pro) in TP53 (Cellular tumor antigen p53) is a protein-truncating change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Li-Fraumeni syndrome. The record also includes experimental measurements and structural context.
R158P (p.Arg158Pro) variant details
- p.Arg158Pro
- NCI-TCGA Cosmic COSV5379
- Uncertain significance
- Li-Fraumeni syndrome
- Frameshift
- ClinVar: Uncertain significance (Li-Fraumeni syndrome)
- EBI: Pathogenic (in sporadic cancers)
- UniProt: Pathogenic (in sporadic cancers)
- Structural context available
- p53 variant effect measured by cell growth: score 0.715