P36W (p.Pro36Trp) variant of TP53 (Cellular tumor antigen p53)
P36W (p.Pro36Trp) in TP53 (Cellular tumor antigen p53) is a protein-truncating change. Clinical records from UniProt describe it as variant assessed as somatic; high impact in the context of in a sporadic cancer. The record also includes variant effect predictions, experimental measurements, and structural context.
P36W (p.Pro36Trp) variant details
- p.Pro36Trp
- NCI-TCGA Cosmic COSV5325
- Variant assessed as somatic; high impact.
- in a sporadic cancer
- Frameshift
- MetaLR 0.80
- MetaSVM 0.47
- SIFT 0.75
- UniProt: Variant assessed as somatic; high impact. (in a sporadic cancer)
- Structural context available
- p53 variant effect measured by cell growth: score -3.65