P34H (p.Pro34His) variant of TP53 (Cellular tumor antigen p53)
P34H (p.Pro34His) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance in the context of in a sporadic cancer. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes experimental measurements and structural context.
P34H (p.Pro34His) variant details
- p.Pro34His
- gnomAD rs1322947350
- Uncertain significance
- in a sporadic cancer
- Missense
- Variant Prioritization Score for Impact Estimate 0.269
- ESM-1b 0.00
- AlphaMissense 0.08
- EBI: Variant of uncertain significance (in a sporadic cancer)
- UniProt: Uncertain significance (in a sporadic cancer)
- Structural context available
- p53 variant effect measured by cell growth: score 0.619