L32R (p.Leu32Arg) variant of TP53 (Cellular tumor antigen p53)
L32R (p.Leu32Arg) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from EBI and UniProt describe it as pathogenic. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes experimental measurements and structural context.
L32R (p.Leu32Arg) variant details
- p.Leu32Arg
- Ensembl rs2151045450
- Pathogenic
- Missense
- Variant Prioritization Score for Impact Estimate 0.282
- ESM-1b 0.02
- AlphaMissense 0.13
- EBI: Pathogenic
- UniProt: Pathogenic
- Structural context available
- p53 variant effect measured by cell growth: score 0.233