L14P (p.Leu14Pro) variant of TP53 (Cellular tumor antigen p53)
L14P (p.Leu14Pro) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes experimental measurements and structural context.
L14P (p.Leu14Pro) variant details
- p.Leu14Pro
- NCI-TCGA TCGA novel
- Ensembl rs2151047655
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- ESM-1b 0.00
- AlphaMissense 0.54
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available
- p53 variant effect measured by cell growth: score -2.41