L14M (p.Leu14Met) variant of TP53 (Cellular tumor antigen p53)
L14M (p.Leu14Met) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes experimental measurements and structural context.
L14M (p.Leu14Met) variant details
- p.Leu14Met
- Ensembl rs1567558112
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- ESM-1b 0.00
- AlphaMissense 0.17
- EBI: Likely benign
- UniProt: Likely benign
- Structural context available
- p53 variant effect measured by cell growth: score -2.41