E11D (p.Glu11Asp) variant of TP53 (Cellular tumor antigen p53)
E11D (p.Glu11Asp) in TP53 (Cellular tumor antigen p53) is a missense change. Clinical records from EBI and UniProt describe it as likely benign in the context of in sporadic cancers. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes experimental measurements and structural context.
E11D (p.Glu11Asp) variant details
- p.Glu11Asp
- Ensembl rs2151047751
- Likely benign
- in sporadic cancers
- Missense
- Variant Prioritization Score for Impact Estimate 0.27
- ESM-1b 0.00
- AlphaMissense 0.07
- EBI: Likely benign (in sporadic cancers)
- UniProt: Likely benign (in sporadic cancers)
- Structural context available
- p53 variant effect measured by cell growth: score -2.37