D21Y (p.Asp21Tyr) variant of TP53 (Cellular tumor antigen p53)
D21Y (p.Asp21Tyr) in TP53 (Cellular tumor antigen p53) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D21Y (p.Asp21Tyr) variant details
- p.Asp21Tyr
- cosmic curated COSV99390
- Ensembl rs2151047361
- Missense
- Variant Prioritization Score for Impact Estimate 0.605
- REVEL 0.74
- ESM-1b 1.00
- AlphaMissense 0.14
- CADD 22.10
- PolyPhen-2 0.11
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- p53 variant effect measured by cell growth: score -3.41